FR: Reversal of respiratory depression caused by suspected narcotic intoxication

• 0.4 mg IM every 3 minutes as required, to maximum of 3 total doses

EMR: Reversal of respiratory depression caused by suspected narcotic intoxication

• 0.4 mg IM every 3 minutes as required, to a maximum of 4 total doses
  • Second dose: 0.4 mg IM if required
  • Third dose: 0.8 mg IM if required
  • Fourth dose: 2 mg IM if required

PCP: Reversal of respiratory depression caused by suspected narcotic intoxication

• 0.4 mg IM/IV every 3 minutes as required, to a maximum of 3 total doses
  • Second dose: 0.4 mg IM/IV if required
  • Third dose: 0.8 mg IM/IV if required
  • Fourth dose: 2 mg IM/IV if required (IV preferred)

ACP: Reversal of respiratory depression caused by suspected narcotic intoxication

• As per PCP schedule
• May also consider, in order:
  1. 4 mg IV
  2. 10 mg IV Requires CliniCall consultation -- 1-833-829-4099

Titrate doses to improve spontaneous respiratory effort.  It is not necessary to administer sufficient naloxone to completely reverse the opioid effects. 

Never administer naloxone to neonates.

Follow weight-based dosing

FR: Not authorized

EMR: Reversal of respiratory depression caused by suspected narcotic intoxication

• 0.1 mg/kg (to maximum of 2 mg per dose), repeated every 3 minutes, to maximum of 4 total doses
  • Higher dose for pediatric patients as they are unlikely to experience withdrawal