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Tranexamic Acid

Hemostatic and antifibrinolytic agent

PCP: Signs of shock or hypoperfusion in association with an injury suggestive of occult or ongoing bleeding

 

  • Hypersensitivity to tranexamic acid
  • Time since injury to administration > 3 hours
  • Age < 12 years (PCP) or < 1 year (ACP) 

PCP: Signs of shock or hypoperfusion in association with an injury suggestive of occult or ongoing bleeding

  • 1 g IV over 10 minutes (via infusion).

Follow weight-based dosing

ACP: Signs of shock or hypoperfusion in association with an injury suggestive of occult or ongoing bleeding

  • < 12 years of age: 15 mg/kg IV over 10 minutes (via infusion)
  • > 12 years of age: 1 g IV over 10 minutes (via infusion).

Prevents clot degradation by competing for TPA receptor sites

Intravenous:

  • Onset: immediate

May potentiate hypotension if administered too quickly

For intravenous infusion use only.  Do not administer as a push dose, or intramuscularly or subcutaneously.

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