Tranexamic Acid
Classification
Hemostatic and antifibrinolytic agent
Indications
PCP: Signs of shock or hypoperfusion in association with an injury suggestive of occult or ongoing bleeding
Contraindications
- Hypersensitivity to tranexamic acid
- Time since injury to administration > 3 hours
- Age < 12 years (PCP) or < 1 year (ACP)
Adult dosages
PCP: Signs of shock or hypoperfusion in association with an injury suggestive of occult or ongoing bleeding
- 1 g IV over 10 minutes (via infusion).
Pediatric Considerations And Dosing
ACP: Signs of shock or hypoperfusion in association with an injury suggestive of occult or ongoing bleeding
- < 12 years of age: 15 mg/kg IV over 10 minutes (via infusion)
- > 12 years of age: 1 g IV over 10 minutes (via infusion).
Mechanism Of Action
Prevents clot degradation by competing for TPA receptor sites
Pharmocokinetics
Intravenous:
- Onset: immediate
Adverse Effects
May potentiate hypotension if administered too quickly
Warning And Precautions
For intravenous infusion use only. Do not administer as a push dose, or intramuscularly or subcutaneously.